Status:
COMPLETED
Red Blood Cells as a Reflection of Endothelial Function in Old Age
Lead Sponsor:
Heinrich-Heine University, Duesseldorf
Conditions:
Red Blood Cells
Endothelial Function
Eligibility:
All Genders
18+ years
Brief Summary
The aim of this study is to find out, how far red blood cells reflect age-depended changes in endothelial function.
Detailed Description
It will be investigated with determination of endothelial function (measured as flow-mediated vasodilation) and of circulated nitric oxid-pool in red blood cells and in blood plasma, how far red blood...
Eligibility Criteria
Inclusion
- Groups 1-3:
- healthy subjects
- informed consent
Exclusion
- hypertension (blood pressure ≥140/90 mmHg),
- hypercholesterolemia (LDL ≥250 mg/dl, HDL ≤45 mg/dl),
- diabetes mellitus (fasting plasma glucose ≥128 mg/dl)
- acute inflammation (CRP \>0.5 mg/dl)
- malignant diseases
- heart failure (NYHA III-IV)
- arrhythmia of high degree
- acute or terminated kidney disease
- cardiovascular diseases ( cardiac artery disease, peripheral vascular disease and cerebrovascular diseases)
- anemia
- pregnancy
- Group 4 :
- Inclusion Criteria:
- angiographical signs of apparent atherosclerosis (cardiac artery disease or peripheral vascular disease or degenerative valvular heart disease)
- informed consent
Key Trial Info
Start Date :
July 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2020
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT02265003
Start Date
July 1 2012
End Date
December 31 2020
Last Update
February 16 2021
Active Locations (1)
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1
University Hospital Duesseldorf
Düsseldorf, Germany, 40225