Status:
COMPLETED
Regulation and Signaling of Red Blood Cell (RBC) Endothelial Nitric Oxide Synthase (eNOS) in Patients With Stable and Unstable Coronary Artery Disease
Lead Sponsor:
Heinrich-Heine University, Duesseldorf
Conditions:
Coronary Artery Disease
Endothelial NO-synthase
Eligibility:
All Genders
40-80 years
Brief Summary
The aim of this study is measurement of expression and activity of RBC eNOS in different clinical cohorts of patients with coronary artery disease and acute coronary syndrome and to investigate the im...
Eligibility Criteria
Inclusion
- informed consent
- for ACS(acute coronary syndrome)-Group: angiographic coronary artery disease; acute coronary syndrome, defined by EITHER unstable angina pectoris with significant coronary stenosis (troponin negative, without significant ST-elevation) OR low-risk NSTEMI (Troponin positive, without significant ST-elevation)
- for stable CAD-Group: angiographic coronary artery disease; no acute coronary syndrome within the last 3 months
- healthy control group: No clinical or angiographical signs of apparent atherosclerosis
Exclusion
- acute inflammation (CRP \> 1 mg/dl, leukocyte \> 11.000/µl)
- malignant diseases
- pregnancy
- medication with NO-donors ( e.g.isosorbide mononitrate, isosorbide dinitrate, glyceryl trinitrate, Molsidomin, Ranexa)
- patients with STEMI or high-risk NSTEMI
Key Trial Info
Start Date :
January 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2020
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT02265016
Start Date
January 1 2014
End Date
December 31 2020
Last Update
February 16 2021
Active Locations (1)
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1
University Hospital Duesseldorf
Düsseldorf, Germany, 40225