Status:
TERMINATED
Parkinson's Disease Exercise TMS PET Study
Lead Sponsor:
Pacific Parkinson's Research Centre
Conditions:
Parkinson Disease
Eligibility:
All Genders
40-80 years
Phase:
NA
Brief Summary
The therapeutic effects of exercise in Parkinson's disease (PD) are commonly reported, however the mechanisms are unknown. The purpose of this study is to investigate the potential mechanisms of exerc...
Detailed Description
Positron Emission Tomography will be used to measure dopamine neuron density, endogenous dopamine release and neuroimflammation. We will also use functional magnetic resonance imaging (fMRI) to measur...
Eligibility Criteria
Inclusion
- Inclusion Criteria: Diagnosed with Parkinson's Disease, Exercise less than 3x per week.
- Exclusion Criteria. Describe which potential participants will be excluded from participation, and list the criteria for their exclusion.
- atypical Parkinson syndrome (progressive supranuclear palsy, multiple system atrophy, drug-induced etc.);
- significant osteoporosis or arthritis;
- other neurological disease/complications (e.g. myopathy, stroke, brain lesion, MS);
- self-reports claustrophobia;
- history of cancer within 5 years of study participation;
- high dose of radiation from other procedures within the year;
- not able to tolerate being off PD medication for up to 24 hours;
- a female subject who is breast-feeding or pregnant.
- Subjects who regularly use anti-inflammatories (only excluded for PBR scans).
- Exclusion criteria for MRI scanning and magnetic stimulation from repetitive Transcranial Magnetic Stimulation (rTMS) scanning includes:
- artificial heart valve;
- brain aneurysm clip;
- electrical stimulator for nerves or bones;
- ear or eye implant;
- implanted drug infusion pump;
- coil, catheter, or filter in any blood vessel;
- orthopedic hardware (artificial joint, plate, screws);
- other metallic prostheses;
- shrapnel, bullets, or other metal fragments;
- surgery or tattoos (including tattooed eyeliner) in the last six weeks;
- brain surgery
- have a cardiac pacemaker, wires or defibrillator;
- have had an injury where a piece of metal lodged in the eye or orbit;
- have a ferromagnetic aneurysm clip; and
- have a history of seizures/epilepsy
- history of severe or uncontrolled headaches/migraines
- taking medications that lower seizure threshold (e.g. amitryptiline, haloperidol)
- Subjects may be excluded following study enrollment if they meet any of the following exclusion criteria:
- significant cognitive impairment or depression;
- significant or unstable cardiovascular or respiratory disease - all subjects will undergo a screening exercise bicycle stress test; or
- failure to comply with the exercise or stretching intervention program by not completing at least 30 of the 36 exercise classes.
- Severe/multiple head trauma(s)
Exclusion
Key Trial Info
Start Date :
November 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 12 2020
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT02265900
Start Date
November 1 2014
End Date
March 12 2020
Last Update
March 17 2021
Active Locations (1)
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1
Pacific Parkinson's Research Centre
Vancouver, British Columbia, Canada, V6T 2B5