Status:
COMPLETED
Role of Omalizumab in Reducing the Incidence of Oxaliplatin-induced Hypersensitivity Reaction
Lead Sponsor:
Yale University
Conditions:
Colon Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Pilot study to evaluate the activity of omalizumab in the prevention of recurrent oxaliplatin hypersensitivity reaction (HSR) in oxaliplatin-sensitive patients. The study will also evaluate the safety...
Detailed Description
This is an open label single arm pilot study studying the effects of omalizumab in the treatment of oxaliplatin hypersensitivity reaction (HSR) for patients with stage IV GI cancer.
Eligibility Criteria
Inclusion
- Clinically evident HSR to oxaliplatin, with symptoms of flushing, urticaria, pruritus, rash, and/or dyspnea without bronchospasm that emerge during or shortly after of oxaliplatin infusion
- Responding (complete or partial) or stable disease according to RECIST criteria while undergoing treatment with oxaliplatin containing regimen or need to resume an oxaliplatin based regimen in the setting of well-documented recent oxaliplatin hypersensitivity reaction
- Histologically confirmed stage IV GI cancer (AJCC 7th edition) currently sensitive to oxaliplatin containing chemotherapy regimen
- Age 18 years or older
- ECOG performance status 0-2
- Adequate bone marrow, liver, and kidney function. (WBC \> 1500 cells/uL, platelets \> 50,000/uL, ALT/AST \< 5xULN (unless due to liver metastasis), Creatinine \< 2.0 mg/ld)
- Willing to give written informed consent, adhere to the visit schedules and meet study requirements
Exclusion
- Prior history of severe reactions to oxaliplatin as characterized by the presence of hemodynamic instability, significant respiratory symptoms or potential airway compromise
- History of hypersensitivity reaction to Xolair or any ingredient of Xolair
- Concurrent therapy with investigational agents
- Use of any other investigational agent in the last 15 days and all toxicity of prior therapy resolved
- Psychological, familial, or sociological condition potentially hampering compliance with the study protocol and follow-up schedule
- Women of childbearing potential not using the contraception method(s), as well as women who are breastfeeding
- Patients with severe medical conditions that in the view of the investigator prohibits participation in the study
Key Trial Info
Start Date :
November 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 27 2018
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT02266355
Start Date
November 1 2014
End Date
February 27 2018
Last Update
May 30 2019
Active Locations (1)
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1
Yale University
New Haven, Connecticut, United States, 06519