Status:
WITHDRAWN
Efficacy of TDCS for Treating Working Memory Dysfunction and Depression in Temporal Lobe Epilepsy
Lead Sponsor:
NYU Langone Health
Collaborating Sponsors:
Epilepsy Foundation
American Epilepsy Society
Conditions:
Epilepsy
Eligibility:
All Genders
18-70 years
Phase:
PHASE1
Brief Summary
Memory difficulty ranks among the most common complaints for patients with temporal lobe epilepsy. While these cognitive problems may affect quality of life more than seizure frequency, no effective t...
Detailed Description
Transcranial direct current stimulation (tDCS) is a powerful technique to modulate brain activity: TDCS is based on the application of a weak direct current to the scalp that flows between two relati...
Eligibility Criteria
Inclusion
- age between 18-70 years
- diagnosis of temporal lobe epilepsy, with seizure focus defined by seizure semiology, EEG, MRI Brain, PET and/or ictal and interictal SPECT.
- Must have a stable seizure frequency in the two (2) months prior to enrollment, as verified by the patient's seizure log and/or clinic notes and without recent antiepileptic medication changes.
- Must score above 22/30 on the Montreal Cognitive Assessment (MoCA).
- Must be able to provide informed consent.
Exclusion
- Patient has a progressive or unstable neurological or systemic disease
- Patient has an ictal focus over the F3 or F4 (DLPFC) field
- Patient has a history of severe depression, as determined by a screen inventory test such as the Beck Depression Inventory or a psychiatrist
- Patient has a history of severe traumatic brain injury or prior brain surgery with skull defect
- Contraindictations to tDCS, including metal in the head or implanted brain medical devices
- Pregnancy
- Any implanted electrical medical device, including pacers and implanted cardiac defibrillators
- History of schizophrenia, schizoaffective disorder, other psychosis, rapid-cycling bipolar illness, alcohol/drug abuse within the past year
- History of dementia
Key Trial Info
Start Date :
November 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2015
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT02268578
Start Date
November 1 2012
End Date
November 1 2015
Last Update
April 15 2016
Active Locations (1)
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1
Neurology
New York, New York, United States, 11106