Status:
WITHDRAWN
The Effect of Metoprolol on Anaesthesia, the Need for Analgesics, and Pain in Breast Cancer Patients
Lead Sponsor:
Kuopio University Hospital
Conditions:
Breast Cancer
Eligibility:
FEMALE
18-65 years
Phase:
PHASE3
Brief Summary
The purpose of the study is to test the effects of metoprolol on anaesthesia and the need for perioperative analgesics in patients undergoing breast surgery. With 12 months follow-up the incidence of ...
Detailed Description
The purpose of the study is to test the effects of intraoperative metoprolol on 1) anaesthetic and alagesic use 2) pain during the early postoperative period and 3) the incidence of pain and lide sati...
Eligibility Criteria
Inclusion
- Elective breast surgery due to breast cancer
- Voluntary
- BMI ≥ 18 and ≤ 35 kg/m2
- ASA 1-3
- No regular use of beta-blockers or during the last 72 hours
- No contraindications to beta-blockers
Exclusion
- Pregnancy or breast feeding
- AV-block, degree II or III
- Untreated cardiac insufficiency
- Sinus bradycardia, heart rate \< 45 / min or symptoms
- Sick sinus syndrome
- Cardiogenic shock
- Severe peripheral vascular disorder
- Systolic blood pressure \< 100 mmHg
- Long PQ-time, \> 0,24 seconds
- Known hypersensitivity to beta-blockers or the ingredients of the drug
Key Trial Info
Start Date :
March 21 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 21 2018
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT02269696
Start Date
March 21 2018
End Date
March 21 2018
Last Update
March 22 2018
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