Status:
COMPLETED
Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry
Lead Sponsor:
AstraZeneca
Conditions:
Acute Coronary Syndromes
Eligibility:
All Genders
18-99 years
Brief Summary
The primary objective of the UPSTREAM Registry is to address the data gap regarding the course of NSTEMI (Non-ST-Elevation Myocardial Infarction)between ED (Emergency Department) arrival and diagnosti...
Detailed Description
This is a Phase IV, post-approval, multicenter, prospective, noninterventional study of consecutive patients with a working diagnosis of NSTEMI (Non-ST-Elevation Myocardial Infarction) and treatment w...
Eligibility Criteria
Inclusion
- Patients (≥18 years of age) with a working diagnosis of NSTEMI and treatment with an OAP agent (ticagrelor, clopidogrel, or prasugrel) either in the ED, or in any case within the timeframe that emergency physicians consider to be "upstream"- i.e., within the first 72 hours of care and at least 4 hours before diagnostic angiography. In addition, only those patients who undergo a diagnostic coronary angiography within 72 hours of ED arrival will be eligible for UPSTREAM.
Exclusion
- Life expectancy less than 90 days in opinion of treating clinician;
- Not undergoing diagnostic angiography within 72 hours of ED arrival;
- Refusal of consent; or
- Unlikely to comply with follow-up by telephone.
Key Trial Info
Start Date :
February 17 2015
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 31 2019
Estimated Enrollment :
2000 Patients enrolled
Trial Details
Trial ID
NCT02271022
Start Date
February 17 2015
End Date
October 31 2019
Last Update
November 3 2020
Active Locations (55)
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1
Research Site
Birmingham, Alabama, United States, 35233
2
Research Site
Mobile, Alabama, United States, 36688
3
Research Site
Little Rock, Arkansas, United States, 72211
4
Research Site
Sacramento, California, United States, 95812