Status:
COMPLETED
Calcium Dobesilate Versus Cabergoline for Prevention of Ovarian Hyperstimulation Syndrome
Lead Sponsor:
Benha University
Conditions:
Infertility
Eligibility:
FEMALE
22-44 years
Phase:
PHASE2
PHASE3
Brief Summary
The purpose of this study is to compare the effect of oral Calcium Dobesilate to oral Cabergoline in the prevention of ovarian hyperstimulation syndrome (OHSS) in high-risk women underwent intracytopl...
Detailed Description
Two hundred and twenty women at risk of ovarian hyperstimulation syndrome during ICSI cycles will be randomly scheduled into two equal groups. In group A, (Calcium Dobesilate group), 1 cap / 8 hs Doxi...
Eligibility Criteria
Inclusion
- Patients enrolled in the study were infertile women undergoing ICSI with one of the following criteria: previous episodes of OHSS, polycystic ovaries (i.e., \> 24 antral follicles present on baseline ultrasound examination), high AMH (\> 3.0 ng/mL), large number of small follicles (8 to 12 mm) seen on ultrasound during ovarian stimulation, high s.E2 at hCG trigger (E2 \>3000 pg/ml or rapidly rising s.E2), presence of \> 20 follicles by ultrasound on day of retrieval or large number of oocytes retrieved (\> 20).
- Exclusion Criteria:
- None
Exclusion
Key Trial Info
Start Date :
April 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT02271360
Start Date
April 1 2014
End Date
December 1 2015
Last Update
February 16 2017
Active Locations (1)
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1
Benha univesity hospital
Banhā, El Qualyobia, Egypt, 13518