Status:
COMPLETED
Human Study of Hydroxytyrosol on Phase II Enzymes in Healthy Subjects
Lead Sponsor:
IMDEA Food
Conditions:
Healthy
Eligibility:
MALE
20-40 years
Phase:
NA
Brief Summary
Explore the detoxifying potential of hydroxytyrosol and its effects on Phase II enzyme expression (leading to xenobiotics detoxification in the liver).
Detailed Description
Hydroxytyrosol is peculiar to olives (and, hence, to olive oil) and is being exploited as a potential supplement or preservative to be employed in the nutraceutical, cosmeceutical, and food industry. ...
Eligibility Criteria
Inclusion
- Male gender with age range 20-40 years
- Signed patient informed consent
Exclusion
- BMI \< 19 and \>26
- Subjects with a diagnosis of diabetes mellitus, dyslipidemia, hypertension and other cardiometabolic diseases.
- Subjects with dementia, mental illness or diminished cognitive function.
- Subjects with serious diseases (hepatic, renal, cardiovascular, etc.)
- Subjects who refuse to make the 24 hour urine collection and blood samples under study.
- Subjects with allergy or intolerance to olive and derivatives.
- Subjects with drug treatment of any kind.
- Current smoking.
Key Trial Info
Start Date :
October 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2015
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT02273622
Start Date
October 1 2014
End Date
January 1 2015
Last Update
March 24 2015
Active Locations (1)
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1
IMDEA-Food
Madrid, Madrid, Spain, 28049