Status:
COMPLETED
MRI and PET-CT for Radiotherapy Planning for Head and Neck Cancer
Lead Sponsor:
The Leeds Teaching Hospitals NHS Trust
Conditions:
Head and Neck Cancer
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
Radiotherapy is commonly used to treat advanced cancers of the head and neck, aiming for cure while preserving patients' quality of life including their ability to speak and swallow. In order to reduc...
Eligibility Criteria
Inclusion
- Age ≥18
- WHO Performance status 02
- Histologically proven squamous cell carcinoma of the head and neck region
- Clinical decision made to proceed with a course of radiotherapy of curative intent of 6670Gy in 3335 fractions over six and a half to seven weeks with or without concurrent chemotherapy
- Measurable primary tumour and/or locoregional metastatic lymph nodes on preradiotherapy imaging
- Able to provide fully informed written consent
- Able to lie flat for 1 hour
- Not be pregnant or breast feeding. Female patients of childbearing potential must agree to use effective contraception, be surgically sterile, or be postmenopausal.
Exclusion
- Hypersensitivity to fluorine-18 FDG
- Hypersensitivity to iodinated contrast media or Gadolinium
- Poorly controlled diabetes
- Acute renal failure or moderate renal impairment (estimated glomerularb filtration rate \< 30 mL/min)
- Contraindication to MRI imaging, including cardiac pacemaker or presence of MRI incompatible metalwork
- Claustrophobia precluding MRI imaging
- Uncontrolled pain
- Urinary incontinence
- Female patients must not be pregnant and if of child bearing age using adequate contraception
- Breast feeding
- Serious psychiatric comorbidity
Key Trial Info
Start Date :
June 1 2011
Trial Type :
INTERVENTIONAL
End Date :
June 1 2013
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT02273778
Start Date
June 1 2011
End Date
June 1 2013
Last Update
August 20 2019
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