Status:
COMPLETED
The Use of EEG in Alzheimer's Disease, With and Without Scopolamine - A Pilot Study
Lead Sponsor:
Mentis Cura
Collaborating Sponsors:
Landspitali University Hospital
Conditions:
AD
Eligibility:
All Genders
60-80 years
Phase:
NA
Brief Summary
The objective of this study is to compare the electroencephalography (EEG) responses of three distinct groups of individuals to scopolamine: 1) a group of Alzheimer Dementia (AD) patients, 2) a group ...
Eligibility Criteria
Inclusion
- Healthy subjects:
- Between 60-80 years of age.
- Volunteers will have to be in good general health as determined by standard physical examination.
- Normal Electrocardiograph (ECG)
- MCI subjects:
- Diagnosed with MCI at the Memory Clinic at the Landspitali University Hospital using F 06,7 according to International Classification of Diseases (ICD) - 10.
- Between 60-80 years of age.
- Subjects need to score between 2 and 3 on the Global Deterioration Scale (GDS).
- Normal ECG
- Alzheimer's patients:
- Diagnosed with AD according to ICD - 10 in Follow up at the Memory Clinic at the Landspitali University Hospital.
- Between 60-80 years of age.
- Subjects need to score between 3-5 on the GDS.
- Normal ECG
- Treated with Reminyl® for the Alzheimer disease.
Exclusion
- Smoking or any other use of tobacco.
- Taking neuroleptics or benzodiazepines (allowed to take oxazepam ad vesp).
- Neurological-, cardiovascular-, gastrointestinal- or genitourinary disorders of medical importance.
- Glaucoma or history of possibly raised intraocular pressure.
- Impaired liver- or kidney function.
- Hypersensitivity to Scopolamine or any component in the formulation.
- Any indication of drug, alcohol or medicine abuse.
- Participation in another investigational study at the same time.
Key Trial Info
Start Date :
April 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2010
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT02273895
Start Date
April 1 2004
End Date
January 1 2010
Last Update
October 24 2014
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