Status:
UNKNOWN
Biomarker Signature of Stroke Aetiology Study: The BIOSIGNAL-Study
Lead Sponsor:
University of Zurich
Collaborating Sponsors:
Swiss National Science Foundation
Conditions:
Stroke, Acute
Eligibility:
All Genders
18+ years
Brief Summary
The three-year cumulative risk of a recurrent stroke, dependent on aetiology, is up to 25 per cent. At present, preventing recurrence relies on a broad approach to reduce risk factors associated with ...
Detailed Description
Objectives and specific aims: The investigators propose to prospectively evaluate the predictive value of the most promising blood bio-markers to identify treatable stroke etiologies on admission and...
Eligibility Criteria
Inclusion
- All consecutive patients (above the age of 18) who are admitted with a suspected ischemic stroke within 24 hours of symptom onset are eligible.
- Ischemic stroke is defined as an acute localized ischemic lesion in the brain not attributable to central nervous system infection, tumor, demyelinating, or degenerative neurologic diseases due to an occlusive vascular disorder.
- Detailed
- Rapid onset of a focal neurologic deficit, with signs or symptoms persisting beyond 24 hours \& NOT associated with:
- infection
- trauma
- tumor of the brain
- severe metabolic disorders
- chronic degenerative neurologic disease
- The development of an acute focal neurologic deficit persisting \>24 hours in conjunction with brain imaging consistent with acute ischemic stroke.
- The CT or MRI may either show a new infarct or no change from the study performed at entry, i.e. the diagnosis is clinical and does not require CT/MRI confirmation. Secondary hemorrhagic infarction is permissible.
Exclusion
- Hemorrhagic stroke
- All patients discharged from the hospital with a diagnosis different from ischemic stroke (i.e. stroke mimics)
Key Trial Info
Start Date :
September 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2021
Estimated Enrollment :
1800 Patients enrolled
Trial Details
Trial ID
NCT02274727
Start Date
September 1 2014
End Date
December 1 2021
Last Update
November 11 2021
Active Locations (9)
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1
University Hospital of Frankfurt
Frankfurt am Main, Germany, 60590
2
Larissa University Hospital of Thessaly
Larissa, Greece, 41110
3
Universitiy Hospital Vall d'Hebron
Barcelona, Spain, 08035
4
Kantonsspital Aarau, Department of Neurology
Aarau, Canton of Aargau, Switzerland, 5001