Status:
COMPLETED
Trajectory of Recovery in the Elderly
Lead Sponsor:
Icahn School of Medicine at Mount Sinai
Collaborating Sponsors:
National Institute on Aging (NIA)
Yale University
Conditions:
Delayed Emergence From Anesthesia
Postoperative Delirium
Eligibility:
All Genders
40-80 years
Phase:
NA
Brief Summary
The purpose of this study is to understand how elderly individuals regain their cognitive skills following general anesthesia. The investigators will compare an age stratified group of volunteers who ...
Detailed Description
Elderly patients undergoing anesthesia and surgery frequently suffer from postoperative cognitive dysfunction (POCD) and postoperative delirium (PD). The cause of these entities is unknown. It is uncl...
Eligibility Criteria
Inclusion
- 40-80 years old
- American Society of Anesthesiologists (ASA) Physical Status I or II (i.e. Individuals with minimal disease burden)
- Capable and willing to consent
Exclusion
- Airway assessment as potentially difficult (Mallampati III or greater)
- Allergies or hypersensitivity to drug or class
- Chronic Inflammatory conditions such a lupus or system rheumatoid arthritis (arthritis limited to 1 or 2 joints will be acceptable)
- Patients with diabetes mellitus
- Patients with a recent illness (within the last 2 weeks)
- Patients with severe visual or auditory disorder/handicaps
- English illiteracy
- Pregnancy
- Participants not expected to be able to complete the postoperative tests
- History of malignant hyperthermia
- Nursing mothers
- Body Mass Index \> 30
- Patients with significant metal implants in body
- Current use of cocaine or opiates
- Current smokers
Key Trial Info
Start Date :
July 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 22 2020
Estimated Enrollment :
104 Patients enrolled
Trial Details
Trial ID
NCT02275026
Start Date
July 1 2015
End Date
April 22 2020
Last Update
June 15 2021
Active Locations (1)
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1
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029