Status:
COMPLETED
Impact of Dexmedetomidine on the Post-Operative Cognition Dysfunction(POCD) in Geriatric Patients
Lead Sponsor:
The First Affiliated Hospital of Anhui Medical University
Conditions:
Postoperative Confusion
Delirium
Eligibility:
All Genders
65-90 years
Phase:
PHASE4
Brief Summary
Post-Operative Cognition Dysfunction (POCD) is a common complication after surgery, POCD can lead to a reduced ability and seriously affect the quality of life of patients, increase personal and socia...
Eligibility Criteria
Inclusion
- Written informed consent
- Selective surgery and general anesthesia patients(abdomen,orthopedics and urology surgery is preferred）；
- Age 65-90 yrs；
- Anesthesia Society of American (ASA) Scale II\~III；
- Anticipated surgery time 2-6 hrs； -
Exclusion
- Dementia patients（Mini-mental state examination\< 20）
- Factors existed that affect cognition assessment such as language,visual,and auditory dysfunction；
- Unstable metal status and mental disease；
- The cognitive function examination in 3-6 months is not anticipated to be completed
- II-III Atrioventricular block；
- Heat rate \< 50 beats/minutes；
- Parkinson's Disease；
- May occur or have occurred the difficult airway or anticipated delayed extubation
- Sure or suspected abuse of analgesic and sedation drug；
- Allergic to the trial drug and other anesthesia drug contraindication； -
Key Trial Info
Start Date :
October 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 20 2017
Estimated Enrollment :
864 Patients enrolled
Trial Details
Trial ID
NCT02275182
Start Date
October 1 2014
End Date
February 20 2017
Last Update
April 25 2018
Active Locations (13)
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1
Anqing Municipal Hospital
Anqing, Anhui, China
2
Affiliated Hospital of Bengbu Medical College
Bengbu, Anhui, China
3
Affiliated Chaohu Hospital of Anhui Medical Hospital
Chaohu, Anhui, China
4
Binhu Hospital of Hefei
Hefei, Anhui, China