Status:
COMPLETED
Prediction of Recurrent Events With 18F-Fluoride
Lead Sponsor:
University of Edinburgh
Collaborating Sponsors:
NHS Lothian
Oxford University Hospitals NHS Trust
Conditions:
Coronary Artery Disease
Myocardial Infarction
Eligibility:
All Genders
50+ years
Brief Summary
This is a multi-centre observational study. It will make use of the positron emission tomography (PET) tracer 18F-sodium fluoride (18F-NaF) as a marker of coronary plaque vulnerability to detect culpr...
Detailed Description
The investigators intend to recruit 700 patients hospitalised with myocardial infarction and proven multivessel coronary artery disease. All patients will undergo a combined CT coronary angiogram (CTC...
Eligibility Criteria
Inclusion
- Patients aged ≥50 years with recent (\<21 days) type 1 myocardial infarction and angiographically proven multi-vessel coronary artery disease defined as at least two major epicardial vessels with any combination of either (a) \>50% luminal stenosis, or (b) previous revascularization (percutaneous coronary intervention or coronary artery bypass graft surgery).
- Provision of informed consent prior to any study specific procedures
Exclusion
- Inability or unwilling to give informed consent
- Women who are pregnant, breastfeeding or of child-bearing potential (women who have experienced menarche, are pre-menopausal and have not been sterilised) will not be enrolled into the trial
- Major intercurrent illness with life expectancy \<2 year
- Renal dysfunction (estimated glomerular filtration rate ≤30 mL/min/1.73 m2)
- Contraindication to iodinated contrast agent, positron emission tomography or computed tomography
- Atrial fibrillation
- Previous recruitment into the trial
Key Trial Info
Start Date :
October 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2022
Estimated Enrollment :
995 Patients enrolled
Trial Details
Trial ID
NCT02278211
Start Date
October 1 2015
End Date
May 1 2022
Last Update
March 17 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Edinburgh Heart Centre
Edinburgh, Lothian, United Kingdom, EH16 4SA