Status:
COMPLETED
Using CBT to Probe Psychobiobehavioral Resilience to Post-trauma Psychopathology
Lead Sponsor:
Rush University Medical Center
Conditions:
Anxiety
Depression
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This randomized controlled trial uses a modularized cognitive behavioral resilience training (MCBRT) intervention to probe risk and resilience mechanisms linked to post-trauma psychopathology. Ninety ...
Eligibility Criteria
Inclusion
- 18 years of age or older
- fluent in English
- history of childhood interpersonal trauma (e.g., sexual assault, physical assault, witnessing assault before age 18)
- mild to moderate distress indicated by a score of 10-20 on the depression scale, 8-14 on the anxiety scale, or 15-25 on the stress scale of the DASS-21.
Exclusion
- severe distress indicated by a score \>20 on the depression scale, \>14 on the anxiety scale, or \>25 on the stress scale of the DASS-21
- DSM-5 criterion A trauma in the past month
- color blindness based on self-report (because of inability to complete the fear conditioning task)
- auditory impairment based on audiometer screening (because of inability to complete the fear conditioning task)
- lifetime psychotic or bipolar disorder
- substance abuse or dependence within past 6 months
- concurrent psychotherapy initiated within 3 months of randomization
- ongoing psychotherapy of any duration directed toward treatment of trauma-related psychopathology (e.g., CBT)
- must be on a stable dose of psychotropic or adrenergically-active medications (e.g., beta blockers) for at least 6 weeks prior to eligibility screening
- mental retardation or significant cognitive impairment
- serious medical illness or instability for which hospitalization may be likely within the next year
- significant suicidal ideation indicated by "yes" on Columbia Suicide Severity Rating Scale item 4 (active suicidal ideation with some intent to act) or enacted suicidal behaviors within 6 months prior to eligibility
- current legal actions related to trauma.
Key Trial Info
Start Date :
July 13 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 26 2019
Estimated Enrollment :
58 Patients enrolled
Trial Details
Trial ID
NCT02279290
Start Date
July 13 2015
End Date
April 26 2019
Last Update
June 11 2021
Active Locations (1)
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1
Rush University Medical Center
Chicago, Illinois, United States, 60612