Status:
COMPLETED
Concomitant Infections of Mansonella Perstans in Tuberculosis and Buruli Ulcer Disease Patients From Ghana
Lead Sponsor:
Kwame Nkrumah University of Science and Technology
Collaborating Sponsors:
University of Bonn
Heinrich-Heine University, Duesseldorf
Conditions:
Mansonella Perstans Infection
Buruli Ulcer
Eligibility:
All Genders
9-55 years
Phase:
PHASE2
Brief Summary
This study will determine the influence of doxycycline treatment against Wolbachia/M. perstans on immunity against concomitant mycobacterial infections in healthy M. perstans infected individuals. In ...
Detailed Description
The purpose of this study is to describe the immune response to Mansonella perstans with or without doxycycline treatment. And to suggest the use of doxycycline for the treatment of Mansonella perstan...
Eligibility Criteria
Inclusion
- M. perstans mg-positive status Good general health without any clinical condition requiring long-term medication.
- Normal renal and hepatic laboratory profiles
Exclusion
- Known intolerance to the doxycycline Body weight \<40 kg Pregnancy or breastfeeding History of severe allergic reaction or anaphylaxis Alcohol or drug abuse
Key Trial Info
Start Date :
October 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 15 2017
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT02281643
Start Date
October 1 2014
End Date
March 15 2017
Last Update
March 23 2017
Active Locations (1)
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1
Agogo Presbyterian Hospital
Agogo, Asante Akim North District, Ghana