Status:
COMPLETED
A Study of RO6926496 in Healthy Volunteers
Lead Sponsor:
Hoffmann-La Roche
Conditions:
Healthy Volunteer
Eligibility:
MALE
18-45 years
Phase:
PHASE1
Brief Summary
This is a single center, randomized, investigator/subject blind, single ascending dose, placebo-controlled, parallel study that will evaluate the safety, tolerability and pharmacokinetics of RO6926496...
Eligibility Criteria
Inclusion
- Healthy male participants, 18 to 45 years of age; healthy status is defined by absence of evidence of any active or chronic disease following a detailed medical and surgical history
- A body mass index between 18 and 30 kg/m2
- Male subjects and their partners of childbearing potential must agree to use 2 methods of contraception, one of which must be a barrier method for the duration of the study
Exclusion
- Positive hepatitis B, hepatitis C, or HIV infection
- History of any clinically significant disease or disorder
- Clinically significant abnormalities in laboratory test results
- Participation in an investigational drug or device study within 90 days prior to screening
- Concomitant disease or condition that could interfere with, or treatment of which might interfere with, the conduct of the study, or that would, in the opinion of the investigator, pose an unacceptable risk to the subject in this study
- History or presence of clinically significant ECG abnormalities
- Smokers who smoke more than 10 cigarettes daily or equivalent and unable or unwilling not to smoke during the in-clinic period
- Any clinically relevant history of hypersensitivity or allergic reactions
- Any familial history of early onset Alzheimer's disease
Key Trial Info
Start Date :
January 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2015
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT02281786
Start Date
January 1 2015
End Date
October 1 2015
Last Update
November 2 2016
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Leeds, United Kingdom, LS2 9LH