Status:
COMPLETED
Platelet Rich Fibrin With 1% Metformin Gel for Treatment of Intrabony Defects
Lead Sponsor:
Government Dental College and Research Institute, Bangalore
Conditions:
Periodontitis
Eligibility:
All Genders
30-50 years
Phase:
PHASE2
Brief Summary
ABSTRACT: Background: Platelet-rich fibrin (PRF) is a second-generation platelet concentrate which releases various growth factors that promote tissue regeneration. Metformin (MF), a member of biguan...
Eligibility Criteria
Inclusion
- Presence of 3- wall intrabony defects ≥3 mm deep (distance between alveolar crest and base of the defect on an intraoral periapical radiograph \[IOPA\] ) along with an interproximal probing depth (PD) ≥5 mm after phase I therapy (scaling and root planing \[SRP\] ) in asymptomatic molar teeth.
Exclusion
- Aggressive Periodontitis subjects
- Subjects with systemic conditions known to affect the periodontal status
- Medications known to affect the outcomes of periodontal therapy
- Hematological disorders and insufficient platelet count (\<200,000/mm3)
- Pregnancy/lactation
- Smoking and tobacco use in any form
- Immunocompromised individuals. Those having unacceptable oral hygiene (plaque index \[PI\]16 \> 1.5) after re-evaluation of Phase I therapy were also excluded from the study.
- In addition, teeth with furcation defects, non vital teeth, carious teeth warranting restorations and mobility of at least grade II were also excluded.
Key Trial Info
Start Date :
November 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT02283554
Start Date
November 1 2013
Last Update
November 5 2014
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