Status:
COMPLETED
Are Uterine Natural Killer Cells Involved in the Initiation of Preterm Labor ?
Lead Sponsor:
Ain Shams University
Conditions:
Preterm Labour
Eligibility:
FEMALE
18-35 years
Brief Summary
Research question: Population of study: women diagnosed as term pregnancy in labor (control) and the other group diagnosed as preterm labor (cases). Intervention: measuring uterine natural killer ce...
Detailed Description
Type of the Study: This is a case control study . Study Settings: This clinical trial will be conducted at Ain Shams University Maternity Hospital and the laboratory work will be done at Ain Shams ...
Eligibility Criteria
Inclusion
- Maternal age: 18-35 years old (to decrease the incidence of preterm labor related to age factor).
- Women who present with viable pregnancy (between 28 and 37 weeks' gestation), and having a threatened preterm labor (which is defined as ≥ 2 uterine contractions at 28-37 weeks' gestation, The onset of labor may be determined by documented uterine contractions (at least one every 10 minutes) and ruptured fetal membranes or documented cervical change with an estimated length of less than 1cm or cervical dilation of more than 2 cm. Threatened preterm labor may be diagnosed when there are documented uterine contractions but no evidence of cervical change.
Exclusion
- Multiple pregnancy.
- Documented uterine anomalies.
- Oligohydramnios and polyhydramnios .
- Medical disorders as Diabetes mellitus and hypertension.
- Preterm premature rupture of membranes.
- Conditions that may have an influence on immune reaction e.g. history of chorioamnionitis.
- Smoking as a risk factor for preterm labor.
- Patients having Autoimmune disorder as it may affect Uterine NK( natural killer ) cells level .
Key Trial Info
Start Date :
August 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT02284867
Start Date
August 1 2012
End Date
December 1 2014
Last Update
February 4 2016
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