Status:
COMPLETED
Circadian Brown Adipose Tissue Metabolism
Lead Sponsor:
University of Pennsylvania
Conditions:
Healthy
Eligibility:
MALE
18-45 years
Phase:
NA
Brief Summary
Brown adipose tissue is poorly understood fat that can metabolize glucose in order to generate heat. Since activated brown fat has a high metabolic rate, it is of great interest as a potential target ...
Detailed Description
Brown adipose tissue is a form of fat that is able to metabolize glucose in order to generate heat. When active, it can convert a great deal of glucose into thermal energy. Activation of brown fat cou...
Eligibility Criteria
Inclusion
- At least 18 years of age and less than 45 years of age
- Able and willing to provide informed consent
- Male gender
- Capable of complying with study procedures and able to lie still in the PET/CT scanner for up to 40 minutes continuously
- Normal fasting glucose (less than 100 mg/dl)
- No evidence of significant concurrent illness
- Follow typical sleep/wake cycle of generally asleep at night and awake during the day
Exclusion
- Prior surgery or radiation to the head, neck, or upper chest (except surgeries such as tonsillectomy/adenoidectomy/tympanostomy that would not be expected, in the judgement of the investigator, to have disrupted the adipose tissue in the neck or the upper chest)
- Active addiction or illicit drug abuse
- BMI greater than 25
- Employment in the night shift/3rd shift
- Unable to remain in the Clinical and Translational Research Center (CTRC) for entire 24 hour period.
- Unable or unwilling to maintain peripheral intravenous access for up to 24 hours
- Abnormal liver or kidney function (serum creatinine or transaminase levels greater than 1.5 ULN)
- Subject has any other condition or personal circumstance that, in the judgement of the investigator, might interfere with the collection of complete, high quality data
Key Trial Info
Start Date :
March 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2015
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT02285270
Start Date
March 1 2014
End Date
April 1 2015
Last Update
December 7 2016
Active Locations (1)
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1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104