Status:
COMPLETED
Effects of CPAP Level on Respiratory Mechanics and Central Drive in Patients With COPD
Lead Sponsor:
Zhujiang Hospital
Collaborating Sponsors:
Guangzhou Institute of Respiratory Disease
Conditions:
Chronic Obstructive Pulmonary Disease (COPD)
Eligibility:
All Genders
40-70 years
Phase:
NA
Brief Summary
Chronic Obstructive Pulmonary Disease (COPD) is a common respiratory disease characterized by airflow limitation that is progressive and not fully reversible. Expiratory flow limitation (EFL) is the m...
Detailed Description
Patients with COPD are divided into two groups: moderate group and severe group, both of which are intervented by CPAP level. The static pressure volume curves of the lung and chest wall (Campbell dia...
Eligibility Criteria
Inclusion
- Patients from Zhu jiang Hospital,Southern Medical University
- Patients aged 40-70 years old
- Patients with pulmonary function test of forced expiratory volume at one second (FEV1)/forced vital capacity(FVC) \< 70% and 30% ≤ FEV1%pred \< 80%
- Patients in a clinically stable state
- Patients who signed informed consent.
Exclusion
- Patients with signs of an airway infection
- Patients with an acute exacerbation during the previous 4 weeks
- Patients with giant bulla(≥3cm in diameter)
- Patients with recent upper abdominal surgery
- Patients with one or more of the following diseases: esophageal cancer, reflux esophagitis, severe obstructive sleep apnea (apnea hypopnea index\>15/hr), neuromuscular disease, or significant heart failure
- Patients with poor compliance.
Key Trial Info
Start Date :
November 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT02285400
Start Date
November 1 2014
End Date
December 1 2015
Last Update
December 31 2015
Active Locations (1)
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1
Zhujiang Hospital,Southern Medical Universtiy
Guangzhou, Guangdong, China, 510282