Status:
UNKNOWN
Evaluation of 4D-contrast Enhanced PET-CT in Tumour Volume Definition
Lead Sponsor:
The Leeds Teaching Hospitals NHS Trust
Collaborating Sponsors:
The Leeds Teaching Hospitals Charitable Foundation
Conditions:
Lung Carcinoma
Lower Oesophageal Carcinoma
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
The aim of high dose radiotherapy treatment is to deliver enough radiation to the tumour to kill all the cancer cells while at the same time giving a low dose of radiation to the normal parts of the b...
Eligibility Criteria
Inclusion
- Age ≥18
- WHO Performance status 02 (Appendix A)
- Histologically proven non small cell lung carcinoma, distal oesophageal carcinoma or pancreatic adenocarcinoma
- Clinical decision made to proceed with a course of radiotherapy of curative intent with or without concurrent chemotherapy
- Measurable primary tumour and/or locoregional metastatic lymph nodes on preradiotherapy imaging
- Able to provide fully informed written consent
- Able to lie flat for 1 hour
- Not be pregnant or breast feeding. Female patients of childbearing potential must agree to use effective contraception, be surgically sterile, or be postmenopausal.
Exclusion
- Hypersensitivity to Fluorine18 fludeoxyglucose (FDG)
- Hypersensitivity to iodinated contrast media
- Poorly controlled diabetes
- Acute renal failure or moderate renal impairment (estimated glomerular filtration rate \< 30 mL/min)
- Claustrophobia precluding imaging
- Uncontrolled pain
- Urinary incontinence
- Female patients must not be pregnant and if of child bearing age using adequate contraception
- Breast feeding
- Serious psychiatric comorbidity
Key Trial Info
Start Date :
June 1 2011
Trial Type :
INTERVENTIONAL
End Date :
December 1 2014
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT02285660
Start Date
June 1 2011
End Date
December 1 2014
Last Update
November 7 2014
Active Locations (1)
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1
Leeds Teaching Hospitals NHS Trust
Leeds, West Yorkshire, United Kingdom, LS9 7TF