Status:
COMPLETED
Study of Morphological and Perfusion Imaging Predictors of Pejorative Outcome in Major Depressive Disorder
Lead Sponsor:
Rennes University Hospital
Conditions:
Depressive Disorder
Eligibility:
All Genders
18+ years
Brief Summary
Depression is a debilitating illness with a risk of developing a treatment resistant form. Currently, diagnosis is purely clinical with little features available to identify potentially adverse develo...
Detailed Description
The main objective is to assess neuroimaging biomarkers like cortical thickness predictive of poor outcome in major depressive disorder. Secondary objectives are : * Identifying neuroimaging biomark...
Eligibility Criteria
Inclusion
- Men and women aged over 18 years;
- Patient with a diagnosis (according to DSM IV criteria measured at MINI) for Major Depressive Episode, and / or recurrent depressive disorder unipolar or bipolar , or chronic and resistant depression (according to the criteria of Thase and Rush);
- Patients will be stratified as the stages of classification and Thase Rush scale widely used to characterize the therapeutic resistance in depression;
- Intensity of EDM with a minimum score of 15 (MADRS);
- Patient in receiving information on the protocol;
- Patient who received information about the protocol and did not express opposition to participate.
Exclusion
- Related to MRI
- Pacemaker or implantable defibrillator;
- Neurosurgical clips;
- Cochlear implants;
- Metal intra orbital or encephalic foreign bodies;
- Stents placed for less than four weeks and osteosynthesis material posed for less than six weeks;
- Claustrophobia.
- Other criteria
- Pregnant or lactating women;
- Hemodynamically unstable acute respiratory failure , a general poor condition or a need for monitoring incompatible with the constraints of MRI ;
- Legal protection ;
- Patients hospitalized without their consent.
Key Trial Info
Start Date :
November 3 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 5 2021
Estimated Enrollment :
179 Patients enrolled
Trial Details
Trial ID
NCT02286024
Start Date
November 3 2014
End Date
August 5 2021
Last Update
February 13 2023
Active Locations (1)
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1
Centre Hospitalier Guillaume Regnier
Rennes, Britanny, France, 35000