Status:
COMPLETED
Effect of NF-кB Dependent Proinflammation on Osteogenic Differentiation of the Mesenchymal Stem Cells in Type 2 Diabetes
Lead Sponsor:
Chiang Mai University
Conditions:
Type 2 Diabetes
Eligibility:
All Genders
18+ years
Brief Summary
This study determines whether NF-кB dependent proinflammatory state found in type 2 diabetes yield to a higher RAGE activation in the mesenchymal stem cell, as well as the effects of the proinflammati...
Detailed Description
This study aims to explore whether proinflammation in type 2 diabetes is an mechanism underlined higher RAGE activation and osteoblast differentiation defect demonstrated in the MSC of type 2 diabetes...
Eligibility Criteria
Inclusion
- Patients with type 2 diabetes who has HbA1c higher than 6.5% with metformin monotherapy and age-matched non-diabetes control subjects who signed consent form to be in the study.
Exclusion
- Patients who use thiazolidinedione, steroid, immunosuppressive medications, antiresorptive agents or anabolic therapy for osteoporosis.
- Patients with elevated serum creatinine higher than 1.4 in female and 1.5 in male.
- Patients with metastases cancer or hematologic malignancy.
Key Trial Info
Start Date :
November 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 3 2018
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT02286128
Start Date
November 1 2014
End Date
May 3 2018
Last Update
July 12 2018
Active Locations (1)
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1
Mattabhorn Phornputkul
Chiang Mai, Thailand, 50200