Status:
COMPLETED
Evaluation de O-(2-[18F]-Fluoroethyl)-L-Tyrosine, a New Tracer PET, in the Diagnosis of Low Grade Glioma
Lead Sponsor:
University Hospital, Toulouse
Conditions:
Low Grade Glioma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Determine the overall discriminatory ability of FET PET in the diagnosis of glioma grade II (referring to the current diagnostic gold standard represented by the histopathology exam of a tumor sample)...
Detailed Description
Low-grade glioma is a malignant tumor of young adults (12.5% of gliomas, incidence of 0.99 / 100,000). Median survival, linked to anaplastic transformation is estimated between 7 and 10 years, with gr...
Eligibility Criteria
Inclusion
- Patients over 18 years
- Diagnosis of glioma grade II referred on clinical and MRI morphologic
- Realization of a brain MRI in preoperative condition of neuronavigation (MRI sequences including axial T2, Flair, T1, T1 with gadolinium) in a within 1 month with FET PET.
- Histological examination scheduled within one month with FET PET by resection (complete or partial) or by biopsy
- Patients who signed informed consent
- No against-indication for PET
- No against-indications to MRI
Exclusion
- Grade II glioma who have received specific treatment with radiotherapy and or chemotherapy.
- Pregnant or breastfeeding women.
- Weight greater than 120 Kg
- against-indication to PET
- against- indication gadolinium
- Possible side effects to MRI (magnetic foreign bodies, pacemaker, congestive severe renal).)
- Patient under guardianship
- No coverage by social security
Key Trial Info
Start Date :
June 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
93 Patients enrolled
Trial Details
Trial ID
NCT02286531
Start Date
June 1 2010
End Date
December 1 2014
Last Update
August 19 2015
Active Locations (3)
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1
CHU de CAEN
Caen, France, 14033
2
Hôpital de la Pitié Salpétrière
Paris, France
3
UHToulouse
Toulouse, France, 31000