Status:
COMPLETED
Cardioventilatory Coupling in Critically Ill Patients
Lead Sponsor:
ASST Fatebenefratelli Sacco
Collaborating Sponsors:
Tommaso Fossali
Stefano Guzzetti
Conditions:
Critically Ill
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
This study measures the cardioventilatory coupling in critically ill patients during mechanical ventilation in controlled mode (pressure controlled) and in patient-driven mode (pressure support and ne...
Detailed Description
Intrathoracic pressure oscillations due to positive pressure ventilation induce cyclic modifications of activity of the pulmonary vascular receptors and cardiac mechanoceptors. These effects changes t...
Eligibility Criteria
Inclusion
- patients consecutively admitted to the mixed intensive care unit of the Luigi Sacco Hospital with (all the following):
- mechanical ventilation with an expected duration ≥ 48 hours
- acute respiratory failure due to ALI/ARDS or COPD exacerbation or pneumonia or severe sepsis/septic shock
- age between 18 and 75 years old
Exclusion
- contraindications to esophageal tube positioning (i.e. esophageal varices, bleeding from upper enteric tract in the past 30 days)
- history of esophageal or gastric or thoracic surgery
- history of neuromuscular disease or stroke or head trauma
- history of thyroidal or adrenal dysfunction
- positive end expiratory pressure ≥ 10 cmH2O and/or inspiratory oxygen fraction ≥ 0.60, or intrinsic positive end expiratory pressure ≥ 8 cmH2O
- needing for neuromuscular blocking drugs administration
- patients unable to undergo to patient-driven mechanical ventilation mode (i.e. coma, excessive sedation)
- mechanical circulatory support (i.e. intra-aortic balloon, extracorporeal membrane oxygenation)
- norepinephrine ≥0.3 mcg/kg/min or epinephrine ≥0.05 mcg/kg/min or dobutamine ≥2.5 mcg/kg/min
- non sinus cardiac rhythm or ectopic beats exceeding ≥5% of normal sinus beats
- acute or chronic heart failure with reduced or preserved ejection fraction
- recent acute miocardial infarct ≤6 months
- recent recovery from respiratory failure or pneumonia or severe sepsis/septic shock ≤30 days
- therapy with beta-blockers
Key Trial Info
Start Date :
September 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2017
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT02286869
Start Date
September 1 2016
End Date
July 1 2017
Last Update
August 1 2017
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Luigi Sacco Hospital
Milan, Italy, 20157
2
Istituto Clinico Humanitas
Rozzano, Italy, 20089