Status:
COMPLETED
Acute Kidney Injury Following Paediatric Cardiac Surgery
Lead Sponsor:
University of Leicester
Collaborating Sponsors:
University Hospitals, Leicester
Heart Link Children's Charity
Conditions:
Acute Kidney Injury
Eligibility:
All Genders
1-17 years
Brief Summary
Acute kidney injury (AKI) complicates over 50% of cardiac surgical procedures in children where it increases morbidity and the use of healthcare resources. The pathogenesis of AKI is poorly understood...
Detailed Description
This is a prospective, single-centre observational feasibility study that will measure changes in MV signalling and their relationship to inflammatory responses after cardiac surgery in children. The...
Eligibility Criteria
Inclusion
- Patients undergoing congenital heart operations with cardio-pulmonary bypass.
- Patients aged ≤ 17 years of age.
- Patients with a body weight \> 2kg.
Exclusion
- Patients with pre-existing inflammatory state: sepsis undergoing treatment, acute kidney injury within 5 days or chronic inflammatory disease.
- Emergency (operation before the beginning of the next working day after decision to operate) or salvage procedure (patients requiring cardiopulmonary resuscitation - external cardiac massage - en route to the operating theatre or prior to induction of anaesthesia. This does not include cardiopulmonary resuscitation following induction of anaesthesia)
- Patients where Extracorporeal Membrane Oxygenation (ECMO) support is required.
- Patients likely to require ECMO postoperatively.
Key Trial Info
Start Date :
October 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
May 1 2017
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT02289040
Start Date
October 1 2014
End Date
May 1 2017
Last Update
January 30 2020
Active Locations (1)
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1
Glenfield Hospital
Leicester, Leicestershire, United Kingdom, LE3 9QP