Status:
COMPLETED
Tau Imaging in Young Onset Dementia
Lead Sponsor:
University of Pennsylvania
Conditions:
Alzheimer's Disease, Early Onset
Logopenic Progressive Aphasia
Eligibility:
All Genders
45-70 years
Brief Summary
The central goal of this study is to determine and compare the similarities and differences in regional brain uptake of \[18F\]T807 in patients with typical Alzheimer's Disease (AD), Posterior Cortica...
Eligibility Criteria
Inclusion
- Participants will be 45 - 70 years of age
- MMSE \> 10 at screening visit.
- Participants must be informed of the investigational nature of this study and provide written informed consent in accordance with institutional and federal guidelines prior to study-specific procedures. If the patient is unable to provide informed consent, the patient's legal representative may consent on behalf of the patient but the patient will be asked to confirm assent.
- Participants must be willing and able to comply with scheduled visits and imaging procedures.
- A brain MRI is required. If a brain MRI has been performed within 6 months of enrollment to this study and of adequate quality that scan may be used for the study analysis, subjects who do not have a brain MRI will undergo a brain MRI either as a part of this study
- Participants must identify a study partner who is willing to accompany the patient to study visits
Exclusion
- Females who are pregnant or breast feeding at the time of screening scan will not be eligible for this study, urine or serum pregnancy test will be performed in women of child-bearing potential at the time of screening
- Inability to tolerate or contraindication to imaging procedures (PET/CT or MRI) in the opinion of an investigator or treating physician
- QTc \> 450 msec on screening ECG.
- Any medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study (e.g. moderate to large stroke or history of moderate or severe traumatic brain injury (TBI)).
Key Trial Info
Start Date :
November 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 31 2019
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT02289118
Start Date
November 1 2014
End Date
January 31 2019
Last Update
March 25 2020
Active Locations (1)
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1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104