Status:
UNKNOWN
Effect of Dexmedetomidine on Levels of Plasma Inflammatory Factor in Asthma Patients Undergoing General Anesthesia
Lead Sponsor:
Second Affiliated Hospital of Xi'an Jiaotong University
Conditions:
Anesthesia
Asthma
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
The study try to illustrate the possible mechanisms of tending to induce airway spasms and the impact of dexmedetomidine on inflammatory reaction in general anesthesia patients with asthma，by detectin...
Eligibility Criteria
Inclusion
- Obtain informed consent
- Elective general anesthesia surgery, surgery time 1 \~ 3 hours.
- 20 patients with a history of asthma.
- 60 patients with no history of asthma.
- American Society of Anesthesiologists (ASA)classification:class I\~II.
- Aged between 18 and 65 years old.
Exclusion
- SBP≥180 mmHg or \<90 mmHg, DBP≥110 mmHg or \<60 mmHg.
- Serious heart, brain, liver, kidney, lung, endocrine diseases or serious infections.
- Hematopoietic dysfunction or bleeding tendency and hemorrhagic disease.
- A neuromuscular system disease.
- Airway and lung surgery.
- Predict possible or happened difficult airway.
- Immune function defect.
- Sure/suspected abuse of narcotic analgesics or drugs or alcohol dependence.
- The test drug allergy or have other contraindications in patients.
- Childbearing age women not to take appropriate contraception, pregnancy or lactation.
- Participated in other clinical drug research in the last 30 days.
Key Trial Info
Start Date :
December 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2015
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT02289391
Start Date
December 1 2014
End Date
December 1 2015
Last Update
November 13 2014
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