Status:
COMPLETED
Development of Countermeasures Against Adverse Metabolic Effects of Shift Work
Lead Sponsor:
Brigham and Women's Hospital
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Circadian Dysregulation
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
The goal of this application is to determine whether changing the timing of food intake prevents the adverse metabolic effects of circadian misalignment.
Detailed Description
Shift work is associated with circadian misalignment and an increased risk for the development diabetes, obesity, and cardiovascular disease. This research will determine whether changing the feeding ...
Eligibility Criteria
Inclusion
- BMI between 18.5 and 29.9 kgm-2
- Healthy adults with regular sleep-wake timing
- Non-smokers
- Completion of medical and psychological screening tests
- Able to spend 14 consecutive days in the sleep laboratory
Exclusion
- BMI \<18.5 or \> 29.9 kgm-2
- History of neurological or psychiatric disorder
- History of sleep disorder or regular use of sleep-promoting medication
- Current prescription, herbal, or over-the-counter medication use
- Traveling across 2 or more time zones within past 3 months
- Donating blood within past 8 weeks
- Worked night or rotating shift work within past 3 years
- Hearing impairment
- Drug or alcohol dependency
Key Trial Info
Start Date :
March 19 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 29 2018
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT02291952
Start Date
March 19 2015
End Date
August 29 2018
Last Update
March 19 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115