Status:
COMPLETED
Study, Double Blind, Randomized, Comparing Two Groups to Evaluate the Safety and Efficacy of Autologous Mesenchymal Stem Cells From Adipose Tissue (CMMAd) in the Treatment of the Faecal Incontinence
Lead Sponsor:
Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud
Collaborating Sponsors:
Iniciativa Andaluza en Terapias Avanzadas
Conditions:
Faecal Incontinence
Eligibility:
All Genders
18-80 years
Phase:
PHASE1
PHASE2
Brief Summary
This is a clinical trial phase I/II, double blind, randomized to compare in two groups of patients to evaluate the safety and efficacy of the autologous mesenchymal stem cells from the adipose tissue ...
Detailed Description
In the phase of recruitment, of 20 months of duration, there will be included 16 participants who will be randomized to one of the groups of intervention (8 patients group CMMAd / 8 patients group pla...
Eligibility Criteria
Inclusion
- Males or females in the age group of 18-80 yrs.
- A unique internal sphincter defect and / or external (no more than 100 º), at any level of the anal canal, of any cause (except those described in the exclusion criteria).
- Severity of faecal incontinence of 12 or more in the Wexner Score and / or at least six episodes of faecal incontinence for a period of 28 days.
- Duration of faecal incontinence of at least two years prior to inclusion.
- Patients who are able to understand the requirements of the study, and willing to provide voluntary written informed consent.
Exclusion
- More of an external sphincter defect and / or at any level of internal anal canal.
- Have received treatment to faecal failure with bulking agents, neuromodulation or surgery.
- Current anorectal tumors.
- Current anal fissures.
- Anorectal stenosis
- Chronic pelvic or anorectal pain.
- Pregnant or 6 months postpartum.
- Medical history of infection with Human Immunodeficiency Virus (HIV) or any severe immunocompromised state or therapy immunosuppressive.
- Malignancies in remission for less than a year before the study. An exception to the basocellular carcinoma (BCC) in "remission" for less than a year.
- Bleeding diathesis or current anticoagulant therapy.
- Chemotherapy during the 6 months preceding the study.
- Previous radiation with evidence of radiation injury in the treated area.
- Participation in any other clinical study during the 3 months preceding the pre-study visit.
- Patients with other serious disorders.
- Patients with uncontrolled inflammatory disease or taking drugs prohibited in the protocol or active perianal disease.
Key Trial Info
Start Date :
October 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2017
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT02292628
Start Date
October 1 2013
End Date
September 1 2017
Last Update
April 17 2018
Active Locations (4)
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1
H. Juan Ramón Jiménez
Huelva, Spain, 21005
2
Fundación Jiménez Díaz
Madrid, Spain, 28040
3
Hospital Regional U de Málaga
Málaga, Spain, 29010
4
Hospital U Virgen del Rocio
Seville, Spain, 41013