Status:
COMPLETED
Early Procalcitonin Kinetics During Empirical Antibiotic Therapy in Critically Ill Patients
Lead Sponsor:
Domonkos Trásy
Conditions:
Bacterial Infections
Eligibility:
All Genders
18+ years
Brief Summary
To investigate the value of procalcitonin (PCT) kinetics between 0-8-16-24 hours after starting empirical antibiotic therapy in critically ill patients, to predict appropriate or inappropriate antibio...
Eligibility Criteria
Inclusion
- Clinical signs of infection
- Suspected or proven acute infection requiring empiric antibiotic therapy as decided by the attending ICU physician
- Suspected site of infection has to be present and documented
- Microbiological sample sent for staining
- Inflammatory markers available at the start of the therapy
Exclusion
- Patients younger than 18 years
- Who received prophylactic or empiric antibiotic therapy 48 hours before inclusion
- Whose receiving acute renal replacement therapy in the first 24 hours following antibiotic treatment
- Following cardiopulmonary resuscitation
- End stage diseases with a "do not resuscitate" order
- Immunocompromised patients (human immunodeficiency virus infection, bone marrow transplantation, malignant haematological disorders and chemotherapy)
- Post cardiac surgery patients
Key Trial Info
Start Date :
October 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2013
Estimated Enrollment :
209 Patients enrolled
Trial Details
Trial ID
NCT02294695
Start Date
October 1 2012
End Date
October 1 2013
Last Update
June 17 2016
Active Locations (1)
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1
Department of Anaesthesiology and Intensive Therapy
Szeged, Csongrád megye, Hungary, H-6725