Status:
COMPLETED
Ventilation-drive Coupling to Evaluate The Efficacy of Inhaled Bronchodilators in Patients With COPD
Lead Sponsor:
Zhujiang Hospital
Collaborating Sponsors:
Guangzhou Panyu Central Hospital
Conditions:
Chronic Obstructive Pulmonary Disease (COPD)
Eligibility:
All Genders
40-70 years
Phase:
NA
Brief Summary
Chronic Obstructive Pulmonary Disease (COPD) is a major cause of chronic morbidity, mortality and disability throughout the world, leading to a heavy social and economic burden.Bronchodilators, the mo...
Detailed Description
Patients were randomly assigned to one of two intervention groups: 1. Group A: Patients inhaled placebo, ipratropium 80μg, salbutamol 400 μg in sequence; 2. Group B: Patients inhaled placebo, salbuta...
Eligibility Criteria
Inclusion
- Patients aged 40-70 years old; Patients with pulmonary function test of FEV1/FVC \< 70% and FEV1%pred \< 50%; Patients in a clinically stable state; Patients who signed informed consent.
Exclusion
- Patients with signs of an airway infection; Patients with an acute exacerbation during the previous 4 weeks; Patients with giant bulla(≥3cm in diameter); Patients with recent upper abdominal surgery; Patients with one or more of the following diseases: esophageal cancer, reflux esophagitis, severe obstructive sleep apnea (apnea hypopnea index\>15/hr), neuromuscular disease, or significant heart failure; Patients with poor compliance.
Key Trial Info
Start Date :
December 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2015
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT02296047
Start Date
December 1 2014
End Date
May 1 2015
Last Update
July 28 2015
Active Locations (1)
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1
Zhujiang Hospital,Southern Medical Universtiy
Guangzhou, Guangdong, China, 510282