Status:
COMPLETED
Phase 1/2 Study of the ERK1/2 Inhibitor BVD-523 in Patients With Acute Myelogenous Leukemia or Myelodysplastic Syndromes
Lead Sponsor:
BioMed Valley Discoveries, Inc
Conditions:
Acute Myelogenous Leukemia
Myelodysplastic Syndrome
Eligibility:
All Genders
18-100 years
Phase:
PHASE1
PHASE2
Brief Summary
This study is being performed to assess the safety, tolerability, and preliminary clinical effects of BVD-523 given orally, twice daily for 21-day cycles, in patients with Acute Myelogenous Leukemia (...
Detailed Description
The study is being performed to assess the safety and tolerability of BVD-523 given orally, twice daily for 21-day cycles. Part 1 of the study will establish dose limiting toxicities (DLT), maximum t...
Eligibility Criteria
Inclusion
- Have either of the following diagnoses:
- Morphologically confirmed acute myeloid leukemia (AML), except acute promyelocytic leukemia (APL), including leukemia secondary to prior therapy or antecedent hematologic disorder (e.g., MDS or myeloproliferative disorders), who have failed to achieve CR or who have relapsed after prior therapy and are not candidates for potentially curative therapy
- Intermediate-2 or High-grade risk MDS (including chronic myelomonocytic leukemia (CMML))
- Have received at least one prior therapy. Patients who are over age 65 and have not received therapy for AML are also eligible, if they are not candidates for induction chemotherapy
- ECOG performance status of 0 to 2
- Predicted life expectancy of ≥ 3 months
- Adequate liver, renal and cardiac function
- For Group 1 in Part 2 of the Study ONLY:
- • Positive for RAS mutation at a Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory prior to study entry
Exclusion
- Concomitant malignancies except carcinoma in situ, basal or squamous cell skin carcinoma; low grade prostate cancer treated with prostatectomy more than 10 years ago; early stage melanoma treated with complete surgical excision more than 5 years ago; carcinoma in situ of cervix treated with cone procedure more than 8 years ago
- Gastrointestinal condition which could impair absorption of study medication
- Uncontrolled or severe intercurrent medical condition
- Patients with rapidly increasing peripheral blood blast counts
- Known uncontrolled central nervous system involvement
- Any cancer-directed therapy within 28 days or 5 half-lives, whichever is shorter
- Any concurrent or prior use of an investigational drug (including MEK inhibitors) within previous 28 days or 5 half-lives, whichever is shorter
- Received chemotherapy regimens with delayed toxicity within the last four weeks (six weeks for prior nitrosourea or mitomycin C). Received chemotherapy regimens given continuously or on a weekly basis with limited potential for delayed toxicity within the last two weeks.
- Ongoing anticoagulant therapy that cannot be held if necessary to permit bone marrow sampling.
- Major surgery within 4 weeks prior to first dose
- Pregnant or breast-feeding women
- Any evidence of serious active infections
- Any important medical illness or abnormal laboratory finding that would increase the risk of participating in this study
- A history or current evidence/risk of retinal vein occlusion or central serous retinopathy
- Concurrent therapy with drugs known to be strong inhibitors of CYP1A2, CYP2D6, and CYP3A4, or strong inducers of CYP3A4
Key Trial Info
Start Date :
November 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 15 2017
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT02296242
Start Date
November 1 2014
End Date
June 15 2017
Last Update
January 29 2019
Active Locations (5)
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1
UCLA Medical Center
Los Angeles, California, United States, 90024
2
Winship Cancer Institute of Emory University
Atlanta, Georgia, United States, 30322
3
Roswell Park Cancer Institute
Buffalo, New York, United States, 14263
4
Perelman Center for Advanced Medicine
Philadelphia, Pennsylvania, United States, 19104