Status:
COMPLETED
Ondansetron's Opposite Effect on Postoperative Analgesia of Acetaminophen
Lead Sponsor:
Mustafa Kemal University
Conditions:
Postoperative Pain
Eligibility:
FEMALE
18-80 years
Phase:
PHASE4
Brief Summary
The purpose of the study is to determine whether the effect of ondansetron on the analgesic effect of acetaminophen. Because 5HT3 blockers prevent the analgesic effects of acetaminophen and also reduc...
Detailed Description
The investigators enrolled 80 American Society of Anesthesiologists Physical Status I-II women 18-80 years old scheduled for hysterectomy under general anesthesia over the course of a year. The study ...
Eligibility Criteria
Inclusion
- Patients 18-80 years old scheduled for hysterectomy
- Horizontal or vertical abdominal skin incision
- Ability to operate a patient-controlled analgesia (PCA) device
- Written informed consent.
Exclusion
- Emergency or urgent procedures
- Women with pre-existing chronic pain at any site requiring opioid analgesia
- Who had a history of significant Axis I psychiatric disease (major depressive disorder, bipolar disorder, schizophrenia, etc.)
- Significant hepatic (alanine aminotransferase or aspartate aminotransferase \>2 times normal) or renal (serum creatinine \>2 mg/dl) impairment
- Allergy to ondansetron or acetaminophen
- Were pregnant
Key Trial Info
Start Date :
May 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT02296333
Start Date
May 1 2014
End Date
December 1 2014
Last Update
March 13 2015
Active Locations (1)
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1
Mustafa Kemal University Medicine Faculty
Hatay, Turkey (Türkiye), 31030