Status:
COMPLETED
Curcumin Addition to Antipsychotic Treatment in Chronic Schizophrenia Patients
Lead Sponsor:
Beersheva Mental Health Center
Collaborating Sponsors:
Tirat Carmel Mental Health Center
Conditions:
Chronic Schizophrenia
Eligibility:
All Genders
18-60 years
Phase:
PHASE4
Brief Summary
Schizophrenia is still remained one of the disabling disorders despite progress in treatment of mental disturbances. Ten to thirty percents of patients have a little or no benefit from treatment with ...
Detailed Description
Study Design This is a 24-week, randomized, double-blind, placebo-controlled investigation of 40 chronic schizophrenia patients. Participants Forty patients will be drawn from the patient population ...
Eligibility Criteria
Inclusion
- Age 18-60 years, male or female
- DSM-IV criteria for schizophrenia.
- Ability and willingness to sign informed consent for participation in the study
- SANS (Scale of Negative Symptoms of Schizophrenia ) \> 30 points
- Fixed antipsychotic dosages at least 3 months
- Steady mental state of patients at least 3 months
Exclusion
- Current substance use disorder except nicotine dependence
- Regular use of NSAID (non-steroidal anti-inflammatory drugs)
- Cancer history
- Untreated or severe hypertension
- Poorly controlled diabetes mellitus Type I or Type II
- Chronic liver \& gallbladder diseases
- Recent GERD (Gastroesophageal Reflux Disorder)
- Neurological disorders: epilepsy, stroke
- Hamilton Depression Scale Hamilton Depression Rating Scale (HAM-D-17 item) \> 24 points
- Patients with a known hypersensitivity to curcumin
- Pregnant women or a woman who intends to become pregnant
Key Trial Info
Start Date :
January 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2017
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT02298985
Start Date
January 1 2015
End Date
May 1 2017
Last Update
January 15 2019
Active Locations (2)
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1
Beersheva Mental Health Center
Beersheva, Israel
2
Tirat Carmel Mental Health Center
Tirat Carmel, Israel, 84170