Status:
COMPLETED
Bacterially-synthesized Folate Absorption Across the Large Intestine
Lead Sponsor:
The Hospital for Sick Children
Conditions:
Healthy
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to determine whether folate produced by bacteria that live in our colon can be absorbed in human colon using a stable isotope method. This study would lead a better unders...
Eligibility Criteria
Inclusion
- 18-65 years;
- overall healthy
Exclusion
- \<18 years or \>65 years
- chronic disease (eg. history of hepatic, gastrointestinal, renal, vascular, haematological or neuropsychiatric disease) or surgery affecting gastrointestinal motility, pH or folate absorption/metabolism
- regular use of medications affecting gastrointestinal pH, motility or folate absorption/metabolism (eg. antiacids, laxatives, phenytoin, sulfasalzine, phenobarbital, primidone, cimetidine, proton pump inhibitors \[such as Nexium\] and antibiotics \[such as Sulfonamides\] or nonsteroidal anti-inflammatory drugs \[NSAIDS, such as aspirin/ibuprofen\])
- consumption of \>1 drink/day of alcohol on a regular basis or current smoking (last 6 months)
- planning a pregnancy, pregnant, breast feeding or the use of high-dose estrogen oral contraceptives/hormone replacement therapy
- known sensitivity to sunscreens containing ultraviolet B filters and/or PABA
- difficulty with swallowing large pills or providing venous blood samples
Key Trial Info
Start Date :
April 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2015
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT02299778
Start Date
April 1 2014
End Date
April 1 2015
Last Update
October 16 2015
Active Locations (1)
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1
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8