Status:
COMPLETED
The Bioavailability Of Sulforaphane From Broccoli Soups Study (BOBS)
Lead Sponsor:
Quadram Institute Bioscience
Collaborating Sponsors:
Biotechnology and Biological Sciences Research Council
Prostate Cancer Foundation
Conditions:
Healthy
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
There is current evidence that suggests eating cruciferous vegetables like broccoli, cauliflower, cabbage is beneficial to our health as they contain compounds which are thought to reduce the risk of ...
Detailed Description
This study will be a randomized, double-blinded, three-phase crossover trial which will investigate the bioavailability of SF following consumption of broccoli + stilton soup containing different conc...
Eligibility Criteria
Inclusion
- Men and women
- Aged 18-65 years
- Non-smokers
- Those that live within 40 miles of IFR
- Those who like broccoli + stilton soups
Exclusion
- Those unwilling/unable to provide urine and blood samples
- Results of the clinical screening indicate, or are judged by the HNU medical advisor to be indicative of a health problem which could compromise the well-being of the participants if they participated, or which would affect the study outcome.
- Those whose vein status is assessed by HNU senior research nurse as unsuitable for cannulation
- Known history of fainting when blood samples are taken, feel unwell or faint during any clinical study day procedures at the HNU
- Women who are or have been pregnant within the last 12 months or who are breast feeding.
- Those diagnosed with any long-term medical condition (e.g. diabetes, haemophilia, cardiovascular disease, glaucoma, anaemia) or requiring medication that may affect the study outcome.
- Smokers
- Those taking dietary supplements or herbal remedies which may affect the study outcome - unless the participant is willing to discontinue taking them for 1 month prior to starting study. Please note that some supplements may not affect the study and this will be assessed on an individual basis
- Those allergic to any of the ingredients in broccoli + stilton soups
- Participants allergic to members of the Brassica family, e.g. mustard allergy (often combined with sensitivity to mugwort pollen, cabbage and peach) or to Brassica pollens (mustard or rapeseed).
- Those taking any prescribed or non-prescribed medication (short or long term), which may affect the study data or participant's wellbeing. This will be assessed by the HNU medical advisor on an individual basis.
- Those on an anti-coagulant therapy or have had anti-coagulant therapy in the past 3 months.
- Parallel participation in another research project that involves dietary intervention
- Any person related to or living with any member of the study team
- Participation in another research project, which involves blood sampling within the last four months unless total blood from both studies does not exceed 470mL (unless the participants are willing to wait 4 months and then be re-screened).
- Those unwilling to provide GP's contact details
- Those unable to provide written informed consent
- Those not suitable to take part in this study because of the screening results
- Those who have donated or intend to donate blood within 16 weeks prior to the study or during the study
- Those with a body mass index (BMI, kg/m2) ≤20 or ≥35 kg/m2
- Depressed or elevated blood pressure measurements (\<90/50 or 95/55 if symptomatic or \>160/100)
- Those that have used antibiotics within the previous one month or on long-term antibiotic therapy.
- Those who are unable to completely finish the 300g portion of broccoli + stilton soup on any of the study days as this will affect study data.
Key Trial Info
Start Date :
October 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2015
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT02300324
Start Date
October 1 2014
End Date
August 1 2015
Last Update
September 17 2015
Active Locations (1)
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1
Institute of Food Research
Norwich, Norfolk, United Kingdom, NR4 7UY