Status:
COMPLETED
Analysis of T Cell and Natural Killer (NK) Cell in Relation to Viral Infections in Pediatric Stem Cell Transplant Patients and Donors
Lead Sponsor:
St. Jude Children's Research Hospital
Collaborating Sponsors:
Michigan State University
Conditions:
Hematologic Malignancies
Eligibility:
All Genders
Up to 21 years
Brief Summary
Viral infections and reactivation during pediatric allogeneic hematopoietic stem cell transplantation (HSCT) are a common occurrence and significantly contribute to post-transplant morbidity and morta...
Detailed Description
PRIMARY OBJECTIVE: * To explore the expansion patterns of KIR+CD56+ T-cells and FcRg-CD56+CD3- NK cells in response to viral infection and reactivation in pediatric allogeneic hematopoietic stem cell...
Eligibility Criteria
Inclusion
- Patients undergoing allogeneic hematopoietic stem cell transplant (HSCT) for a hematologic malignancy or a donor for a patient undergoing allogeneic hematopoietic stem cell transplant for a hematologic malignancy.
- For HSCT patients: ages birth to 21 years old; for donors: any age.
- For minors less than 18 years old, both parents must be available on St. Jude campus to provide consent. One parent/legal guardian will be acceptable if one parent is deceased, incompetent, or when the one parent present has legal responsibility for the care and custody of the child.
Exclusion
- Patients undergoing allogeneic hematopoietic stem cell transplant for a disease other than a hematologic malignancy
Key Trial Info
Start Date :
October 13 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 6 2017
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT02301065
Start Date
October 13 2016
End Date
February 6 2017
Last Update
July 17 2017
Active Locations (1)
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1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105