Status:
TERMINATED
Optimization of Fluid Therapy in Sepsis by a Passive Leg Raising Test
Lead Sponsor:
Karolinska Institutet
Collaborating Sponsors:
Region Stockholm
Svenska militärläkarföreningen
Conditions:
Shock, Septic
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
A randomized controlled clinical trial to evaluate whether a passive leg raising test to guide fluid therapy of patients with septic shock can reduce fluid balance and weight gain. Patients will be tr...
Eligibility Criteria
Inclusion
- All patients \>18 years admitted to the ICU diagnosed with circulatory shock due to suspected sepsis or pancreatitis. Circulatory shock is defined as MAP\<70 mm Hg or need for norepinephrine despite resuscitation with ≥30 ml/kg of crystalloid fluids.
Exclusion
- \> 12 hours have passed after onset of shock. The patient has contraindications for an arterial femoral/axillary line. Elevated ICP. Patients who have had a femoral amputation. Elevated intraabdominal pressure\>20 cm H2O.
- Suspension criteria: The patient has developed pulmonary oedema during PLR test. Life threatening bleeding.
- Serious adverse events:
- Trombosis in arteria femoralis. Death during the study period.
Key Trial Info
Start Date :
February 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2016
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT02301585
Start Date
February 1 2014
End Date
February 1 2016
Last Update
February 9 2016
Active Locations (1)
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1
Karolinska Institutet Södersjukhuset
Stockholm, Sweden, 11883