Status:
TERMINATED
A Study of Glembatumumab Vedotin as Monotherapy or in Combination With Immunotherapies in Patients With Advanced Melanoma
Lead Sponsor:
Celldex Therapeutics
Conditions:
Melanoma
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This study will examine the effectiveness and safety of glembatumumab vedotin as monotherapy or in combination with immunotherapies in patients with advanced melanoma.
Detailed Description
Glembatumumab vedotin consists of an antibody attached to a drug, monomethyl auristatin E (MMAE), that can kill cancer cells. The fully human antibody is designed to deliver the drug to cancer cells b...
Eligibility Criteria
Inclusion
- Among other criteria, patients must meet all of the following conditions to be eligible for the study:
- Unresectable, histologically-confirmed advanced (Stage III or Stage IV) melanoma
- Disease progression during or after the last anticancer therapy received. For Cohort 3, progression must have occurred during the PD-1 targeted CPI (checkpoint inhibitor) treatment and the investigator has deemed it appropriate to continue treatment with the PD-1 targeted CPI beyond confirmed disease progression
- No more than one prior chemotherapy-containing regimen for advanced disease.
- Prior treatments received must include at least one CPI inhibitor (e.g., anti-CTLA-4, PD-1-, PD-L1-targeted immunotherapy) and for patients with a BRAF mutation at least one BRAF- or MEK-targeted therapy, unless patients are not candidates for, or refused, these therapies. For cohort 3, prior treatment received must include a PD-1 targeted CPI administered during the most recent disease progression and for patients with BRAF mutation at least one BRAF- or MEK-targeted therapy when appropriate
- The study site will submit paraffin-embedded tumor tissue obtained from the patient for gpNMB analysis. Patients may require a biopsy if recent tumor tissue is not available. Patients in cohort 2 and 3 must submit a recently obtained biopsy of the skin fold for gpNMB analysis. Patients in Cohort 4 will submit a tumor tissue sample while on study.
- Eastern Cooperative Oncology Group (ECOG) Performance Status 0 to 1
- Adequate bone marrow, liver and renal function.
Exclusion
- Among other criteria, patients who meet any of the following conditions are NOT eligible for the study:
- Previously received glembatumumab vedotin (CR011-vcMMAE, CDX-011) or other MMAE-containing agents
- Treatment with the following therapies before the planned start of study treatment:
- BRAF or MEK inhibitors within 2 weeks
- Monoclonal based therapies within 4 weeks except for the PD-1 targeted checkpoint inhibitor in cohort 3
- Immunotherapy (tumor vaccine, cytokine, or growth factor given to control the cancer) within 2 weeks
- Chemotherapy within 21 days or at least 5 half-lives (whichever is longer)
- Investigational therapy within 2 weeks (or at least 5 half-lives, whichever is longer)
- Patients with ocular melanoma
- Neuropathy that is moderate (Grade 2) or worse.
- Cancer that has spread to the brain or spine will be discussed with the study sponsor and may exclude patients from the trial.
- History of another cancer except:
- Patients with adequately treated and cured non-melanoma skin cancer or in situ cancer
- Patients with any other cancer from which the patient has been disease-free for ≥ 3 years
- Significant cardiovascular disease
- Previously received varlilumab or any other anti-CD27 mAb (Cohort 2 only)
- Active systemic infection requiring treatment
- Treatment with immunosuppressive medications within 4 weeks or corticosteroids within two weeks
- Patients with interstitial lung disease (Cohort 3 only)
- Patients with active diverticulitis (Cohort 3 only)
- Any non-study vaccination within 4 weeks, or influenza vaccine within 2 weeks, prior to CDX-301 dosing (Cohort 4 only)
Key Trial Info
Start Date :
November 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 3 2018
Estimated Enrollment :
132 Patients enrolled
Trial Details
Trial ID
NCT02302339
Start Date
November 1 2014
End Date
October 3 2018
Last Update
September 6 2019
Active Locations (14)
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1
The Angeles Clinic and Research Institute
Los Angeles, California, United States, 90025
2
Northern California Melanoma Center/St. Mary's Medical Center
San Francisco, California, United States, 94117
3
Florida Cancer Specialists
Fort Myers, Florida, United States, 33916
4
Mount Sinai Comprehensive Cancer Center
Miami Beach, Florida, United States, 33140