Status:
TERMINATED
Relationship Between Protein Biomarkers in Cerebrospinal Fluid and Alzheimer&Apos;s Disease in Patients With Depression
Lead Sponsor:
Institut Investigacio Sanitaria Pere Virgili
Conditions:
Alzheimer's Disease
Eligibility:
All Genders
18-60 years
Brief Summary
It is currently accepted that depression during midlife is a risk factor for Alzheimer's disease (AD). Furthermore, several prospective population studies have demonstrated that depression is an indep...
Detailed Description
Groups of subjects: patients with recent apparition of late life depression without fulfilling the dementia criteria (Global Deterioration Scale, GDS, stages 1, 2 and 3). A longitudinal, prospective p...
Eligibility Criteria
Inclusion
- \>= 60 years.
- GDS (Reisberg Gobal Dementia Scale) of 2 to 3.
- Geriatric Depression Scale of Yesavage \>=12.
- History of previous depressive episodes resolved, but the emotional situation 15 months before inclusion, necessarily have to be normal.
Exclusion
- Established dementia of any cause, or secondary degenerative dementia of any origin
- Primary diagnosis of cognitive impairment with psychiatric illness (schizophrenia , bipolar disorder, personality disorders ... )
- Dual diagnosis of chronic depression, dysthymia more than 15 months duration, or major depression with psychotic or atypical symptoms
- Neuroimaging with significant chronic vascular involvement
- To take drugs with known side effects on cognition and it is suspected that the neuropsychological deficits.
- Moderate or severe sensory deprivation or functional illiteracy in the neuropsychological study can not be performed
- Neoplastic diseasesContraindication to performing a lumbar puncture
Key Trial Info
Start Date :
January 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2018
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT02303158
Start Date
January 1 2014
End Date
October 1 2018
Last Update
October 9 2018
Active Locations (1)
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1
Hospital de Tortosa, Verge de la Cinta
Tortosa, Tarragona, Spain, 43500