Status:
COMPLETED
Methylene Blue Intravenously and Chronic Neuropathic Pain
Lead Sponsor:
Uppsala University
Conditions:
Neuropathic Pain
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Aim of Investigation Methylene blue (MB) is a diaminophenothiazine with antioxidant, anti-inflammatory properties and with inhibitory effects on nitric oxide. The aim of this study was to determine th...
Detailed Description
Patients Study participants were screened from a pool of patients with chronic treatment resistant neuropathic pain and were eligible to participate in the study after giving written informed consent ...
Eligibility Criteria
Inclusion
- Female or male subjects \> 18 years of age
- Be able to understand and comply with the requirements of the study
- Patients with a history of persistent peripheral and central neuropathic pain interfering with daily activities of at least 3 months duration
- Patients with previous unsuccessful treatment of neuropathic pain
- Spontaneous or evoked pain upon standardized test (mechanical, movement)\> 50 on a 100 mm VAS scale
- Informed written consent
Exclusion
- Any condition that may confound assessment of pain (acute pain)
- Any condition/disease that could interfere with the study measurements, e.g. peripheral vascular disease, diabetes mellitus, alcohol/opioids addiction
- Noncooperation, insufficient Swedish language
- Treatment with antidepressants, antiepileptics, opioids, lidocaine patches was not accepted the day before and the day of the visit
- Pregnancy
- Treatment with NO releasing drugs, anti-cytokine therapy
- Diabetes mellitus type I, malignancy, increased pulmonary hypertension, cardiac ischemic disease, decreased glomerular filtration rate\<30 ml/min, decreased liver function, Glu-6-PDH deficiency
Key Trial Info
Start Date :
March 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2014
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT02303886
Start Date
March 1 2009
End Date
November 1 2014
Last Update
December 1 2014
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