Status:
COMPLETED
Tenofovir Pharmacology in Older HIV Infected Individuals
Lead Sponsor:
University of Colorado, Denver
Collaborating Sponsors:
University of California, San Francisco
Conditions:
HIV
Aging
Eligibility:
All Genders
18+ years
Brief Summary
Tenofovir continues to play a vital role in the treatment of the human immunodeficiency virus (HIV) and as the age of the HIV-infected population increases in the United States and worldwide, there is...
Detailed Description
Despite a growing population of older HIV infected persons world-wide, major knowledge gaps exist with regards to the pharmacokinetics and pharmacodynamics of antiretroviral drugs in older persons. In...
Eligibility Criteria
Inclusion
- Participants must be between either 18-30 years or \>60 years of age
- Participants must be HIV-positive and receive care from the Infectious Disease (IDGP) Clinic at the University of Colorado Hospital
- Participants must have a history of consistent antiretroviral therapy with a qualifying regimen that includes TFV for at least one year
- Participants must have a suppressed HIV-RNA load (\<48 copies/mL on consecutive visits) while on a TFV-based regimen
Exclusion
- eGFR \< 50 ml/min/1.73 m2
- Use of concomitant nephrotoxic agents (aminoglycosides, amphotericin, cyclosporine, etc.)
- Allergy to iodine and/or iohexol
- Uncontrolled, un-medicated hyperthyroidism
- Plans to relocate out of state in the next year
- Currently pregnant or plans to become pregnant in the next year, currently breastfeeding
- Weight ≥ 300 lbs
- Bilateral hip replacements, bilateral hip pins or screws, metallic rods or spinal fusion devices in the lumbar spine
- Any medical, social, or mental-health issue(s) that, in the opinion of the investigators, could interfere with the study outcomes
Key Trial Info
Start Date :
February 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2016
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT02304263
Start Date
February 1 2015
End Date
September 1 2016
Last Update
September 26 2016
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