Status:
COMPLETED
PRF Growth Factors Levels in Diabetic Patients With Chronic Periodontitis
Lead Sponsor:
Bulent Ecevit University
Conditions:
Diabetes Mellitus
Chronic Periodontitis
Eligibility:
All Genders
40-65 years
Brief Summary
Diabetic patients may show different release of growth factors when microvascular complications such as; retinopathy or periodontitis are seen. Diabetes have an adverse effect on periodontal health an...
Detailed Description
The aim of the investigators study was to evaluate levels of platelet derived growth factor-AB (PDGF-AB), vascular endothelial growth factor ( VEGF),transforming growth factor-beta1 and beta 2 (TGF-β1...
Eligibility Criteria
Inclusion
- CP patients required a diagnosis of moderate to advanced CP and showing radiographic evidence of bone loss and, defined as clinical attachment loss with a minimum of 6 teeth having periodontal pocket greater than 4 mm, a minimum of 20 natural teeth,
- No periodontal treatment in the prior 6 months.
- T2DM patients who had HbA1c levels between 6%-8 %
- Periodontally healthy subjects (periodontal pocket depth \< 4 mm)
Exclusion
- If they had any known systemic diseases other than type 2 diabetes mellitus
- Patient had been under medicine treatment for at least 6 months except patients with diabetes who were treated with stable doses of hypoglycemic agents
- Patients with major complications of DM (i.e., cardiovascular and peripheral vascular diseases
- Insufficient platelet count (\<200,000/mm3); 2) pregnancy/lactation )
- Tobacco use
- Pregnancy
Key Trial Info
Start Date :
March 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2014
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT02304497
Start Date
March 1 2013
End Date
November 1 2014
Last Update
December 2 2014
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