Status:
COMPLETED
99Tc-MDP in Postmenopausal Women With Differentiated Thyroid Cancer and Osteoporosis
Lead Sponsor:
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Conditions:
Differentiated Thyroid Cancer
Osteoporosis
Eligibility:
FEMALE
45+ years
Phase:
NA
Brief Summary
Postmenopausal women with differentiated thyroid cancer (DTC) taking suppressive doses of levothyroxine (L-T4) are thought to have accelerated bone loss and increased risk of osteoporosis. Therefore, ...
Detailed Description
Differentiated thyroid cancer (DTC) has become one of the most common endocrine malignancies. According to American Thyroid Association (ATA) and Chinese Thyroid Association (CTA), most of DTC patient...
Eligibility Criteria
Inclusion
- (1) They were pathologically diagnosed with DTC including papillary or follicular carcinoma. (2) They received a near total thyroidectomy and radioiodine treatment. (3) TSH suppression should be at least one year before the study. (4) Bone mineral density (BMD) in lumbar spine and/or hip was tested by Dual-energy X-ray absorptiometry (DXA) at baseline, 6 month (m) and/or 12m follow up. 5) The diagnosis of osteoporosis was T-score ≤-2.5 SD at the lumbar spine, or hip.
Exclusion
- patients having medications for osteoporosis before TSH suppression treatment;
- secondary osteoporosis ;
- severe liver or kidney disease;
- myelosuppression;
- digestive disease;
- long term use of immunosuppressive agent, estrogen or estrogen receptor modulators. This study was approved by the Institutional Review Board of Hospital Research Ethics. All the patients were fully acquainted with their treatment and consented to participate in the clinical trial.
Key Trial Info
Start Date :
January 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 30 2019
Estimated Enrollment :
142 Patients enrolled
Trial Details
Trial ID
NCT02304757
Start Date
January 1 2015
End Date
December 30 2019
Last Update
November 17 2021
Active Locations (1)
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1
Nuclear Medicine Xinhua Hospital
Shanghai, Shanghai Municipality, China, 200092