Status:
COMPLETED
Prognostic Value of Tissue Factor (TF) in Blood t in Colorectal Cancer in Adults
Lead Sponsor:
University Hospital, Lille
Conditions:
Colorectal Cancer
Eligibility:
All Genders
18+ years
Phase:
EARLY_PHASE1
Brief Summary
Severity of colorectal cancer (CRC) is evaluated by its local staging, locoregional and general ( presence of metastases , usually liver ). This is the most common cancer in France and, despite surgic...
Detailed Description
The study is to measure the TF in the blood, as well as ACE, C reactive protein and E-selectin. The TF will also be measured in the tissue removed during surgery.
Eligibility Criteria
Inclusion
- All patients, adults, holders of CRC with or without MH in whom surgical resection HEALING is planned .
- For witnesses:
- \- Patients without CCR (preoperative colonoscopy). This control population will verify normal values regulators of angiogenesis recently defined and specificity of these vis-à-vis markers CCR-
Exclusion
- all situations where the plasma levels of FT antigen are high, in particular:
- Patients with unstable angina or myocardial infarction in the acute phase (not older than two months)
- Severe sepsis (hospitalization)
- Cirrhosis stage Child C
- Chronic renal failure requiring renal replacement extra
- Patients with microvascular complications of diabetes
- Vasculitis
- Pregnancy and lactation patient on oral contraceptives, or having hormone replacement therapy for menopause
- Patients with extrahepatic metastases
- Patients underwent emergency surgery
- Persons not able to consent
- For witnesses:
- History of cancer, inflammatory disease, diabetes, regular intake of anti inflammatory drugs.
- If during colonoscopy, colorectal cancer was detected, the control patients were excluded from the study -
Key Trial Info
Start Date :
June 22 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 26 2015
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT02304978
Start Date
June 22 2009
End Date
May 26 2015
Last Update
December 26 2025
Active Locations (1)
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1
Service de Chirurgie Digestive et de transplantation Hôpital Claude HURIEZ
Lille, France, 59037