Status:
TERMINATED
Study of Tumor Metabolism by Isotopic Tagging in Patients With High-grade Glioma (CARBONOMIC)
Lead Sponsor:
University Hospital, Grenoble
Collaborating Sponsors:
National Cancer Institute, France
Conditions:
High-grade Glioma
Eligibility:
All Genders
18-90 years
Phase:
PHASE1
Brief Summary
The purpose of the study is to follow tumoral proteins metabolism by in vivo no radioactive isotopic tagging (carbon 13 and nitrogen 15).
Detailed Description
The project aims to study protein turnover in glioblastoma using mass spectrometry after 13C-valine incorporation. This will allow to identify proteins in circulation secreted by tumor which could be ...
Eligibility Criteria
Inclusion
- more or equal than 18 years old
- patient affiliated to social security or similarly regime
- informed consent form signed
- High-grade Glioma tumor suspicion
- Resective surgery indication
- Hematological assessment :
- neutrophils \> 1500/mm3
- Platelet \> 150 000
- blood Creatinin normal
- alkaline Phosphatases and transaminases no more than two times normal
- Bilirubin \< 1.5 times normal
Exclusion
- Pregnant women and lactating mothers
- Ward of court or under guardianship
- Adult unable to express their consent
- Person deprived of freedom by judicial or administrative decision
- Person hospitalized without their consent
- Person under legal protection
- Precedent complete macroscopic tumor resective surgery
- No valid inclusion criteria
- Intratumoral hemorrhage MRI detected
- Treatment anticoagulant or antisludge treatments
- Active Infections and non controled or medical affection or psychiatric intercurrent non treated
- Evolutive cerebral oedema without corticoid response
- Non controled Epilepsy without antiepileptics response
- Karnofsky score \< 40%
- Weight \> 100 kg
- No possibility of resective surgery
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 30 2018
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT02305056
Start Date
September 1 2014
End Date
January 30 2018
Last Update
May 9 2018
Active Locations (1)
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1
CLINATEC
Grenoble, France, 38000