Status:
COMPLETED
Effect of Obesity-derived Cytokines on Protein Turnover and Carbohydrate Metabolism in Human Skeletal Muscle
Lead Sponsor:
University of Nottingham
Collaborating Sponsors:
Biotechnology and Biological Sciences Research Council
Conditions:
Obesity
Sarcopenia
Eligibility:
MALE
55-75 years
Phase:
NA
Brief Summary
Obesity in humans has been shown to result in the increased release of small inflammatory-inducing proteins, called cytokines, from the fat cells of the body. The investigators are interested in the e...
Detailed Description
Recruitment of subjects: 24 obese (but otherwise healthy) participants with elevated cytokine levels and 24 non-obese subjects with normal cytokine levels will be recruited. Following the first exper...
Eligibility Criteria
Inclusion
- Male
- 55-75 years old
- Body Mass Index 20-25 or \>30 kg/m2
- Residing in Nottinghamshire area
Exclusion
- Taking statin medication
- Clotting disorders of previous central venous access (CVA) / thrombosis-inducing activity (TIA)/ deep vein thrombosis (DVT)
- Metabolic disease e.g. diabetes, thyroid dysfunction
- Inflammatory conditions e.g. Rheumatoid Arthritis, Crohn's Disease
- Tobacco smoker in previous 3 years
- Lower limb circulation problems e.g. Claudication
- Epilepsy
- Renal pathology
- Respiratory problems including asthma
Key Trial Info
Start Date :
October 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2012
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT02305069
Start Date
October 1 2009
End Date
September 1 2012
Last Update
December 2 2014
Active Locations (1)
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1
David Greenfield Physiology Laboratories
Nottingham, Nottinghamshire, United Kingdom, NG7 2UH